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With regard to comorbidity, it is important to note that hyperuricemia and gout may coexist with other accompanying conditions, such as diabetes mellitus, obesity, metabolic syndrome, and hypertension, highlighting the important multidisciplinary approach, required for their management

The prolonged activation of macrophages and microglia has been associated with the increased production of ROS (Hemmati et al., 2020) and eventually results in oxidative stress (Zhang et al., 2020)

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J Orthop Surg Res 18 , 386 (2023)